If you still want 4 units per box against the wall, but don't like downward-firing drivers into the floor, you can make the 4th woofer fire upward (don't let the cat climb up on it though; some suitable grille - which I dislike - can help). The box shouldn't be a cube, an upright shape (or horizontal, if you have room) is better with unequal sides. Probably about 200L volume might do, but that needs to be calculated. W600xD500xH800mm might be a starting point (or narrower and taller if room allows or dictates).
The drivers you posted may perhaps go down to 20Hz but with a marked diminished output at that freq., I think. As to room modes (directed, diagonal, etc.) - you'll get them in any room and these can be calculated. But as I and others found out many times real life results differ from calculated ones. The story is that anything present in the room, furniture, etc. do interfere with the pure calculations. You'll need to test.
F = c/2 * sqrt(p^2/L^2 + q^2/W^2 + r^2/H^2)
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F= Frequency
c = speed of sound (1130 feet per second or 344 meters per second)
sqrt = Square Root
^2 = squared
L = Length of Room
W = Width of Room
H = Height of Room
Values for p, q and r are p=1, q=0, r=0 for axial mode; p=2, q=0, r=0 for 2nd axial mode; p=1, q=1, r=0 for first tangential modes.
This is a basic formula, there are more 2nd degree modes, harmonics, etc. and more evolved formulas.
Some acousticians call these modes "room excitation" which sounds grand but I think is a bit of a misnomer. On a time axis, they diminish, not increase or "excite", as their energy diminishes. But they can create momentary peaks and nulls at certain freqs. Their harmonics are more diminished, but still present. That's why some bass-treat their room with acoustic absorbers in corners and other "strategic" points.
Then there's the Q you choose for the subwoofer, inner damping materials, bracing, and so much more. The Q can be manipulated to a degree with miniDSP. The difference would roughly be between a "tak" attack type bass note to a "thak" down to a "Wwahh" attack sound - and anything in between. Hifi subwoofers are not car subwoofers. The latter is a noisy environment that drowns and masks most - possibly all - distortions. Bottom line, this is a business of compromises between many parameters. Good luck.